评估适应热的表型的分子生物标志物:一个叙事范围审查
J Corbett1, J S Young2, M J Tipton3
1Extreme Environments Laboratory, School of Sport Health and Exercise Sciences, University of Portsmouth, Portsmouth, UK. jo.corbett@port.ac.uk.
The journal of physiological sciences : JPS
|October 17, 2023
概括
热适应 (HA) 提高了耐热性,但测量其有效性是困难的. 目前的分子生物标志物缺乏准确性,需要进一步研究多系统方法以进行更好的评估.
科学领域:
- 环境生理学环境生理学
- 分子生物学分子生物学
- 运动科学 运动科学 运动科学
背景情况:
- 热适应 (HA) 对于减轻热应激和改善在炎热环境中的身体表现至关重要.
- 目前评估HA疗效的方法依赖于生理生物标志物,由于后勤,时间和成本的限制,这些通常是不切实际的.
- 一个可靠的HA分子生物标志物将简化热适应的评估.
研究的目的:
- 审查评估热适应 (HA) 的候选分子生物标志物.
- 评估目前HA的分子生物标志物候选者的敏感性和特异性.
- 探索未来发展热适应状态的有效分子生物标志物的方向.
主要方法:
- 关于热适应分子生物标志物的现有文献的叙事综述.
- 基于灵敏度和特异性的候选分子生物标志物的分析.
- 讨论多变量方法和未来的研究需求.
主要成果:
- 目前的HA分子生物标志物候选者表现出敏感性和特异性较差.
- 没有单个分子生物标志物能够成为热适应状态的明确指标.
- 多变量方法显示出潜力,但面临着重大发展挑战.
结论:
- 目前还缺乏用于热度适应的单一可靠的分子生物标志物.
- 未来的研究应该集中在多变量策略和克服确定的挑战,以开发有效的生物标志物.
- 准确评估热适应仍然是进一步研究的关键领域.
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