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怀孕和平价是否与端粒长度有关? 一个系统的审查
Nourit Houminer-Klepar1, Shiran Bord2, Elissa Epel3
1School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Mount Carmel, 31905, Haifa, Israel. nhouminer@gmail.com.
BMC pregnancy and childbirth
|October 17, 2023
概括
生殖力可能会影响生物衰老. 这次审查发现,虽然一些研究表明,更多的孩子与较短的端粒长度 (TL) 有关,但怀孕本身可能不会显著改变TL. 为了更清晰,需要进一步的研究.
科学领域:
- 生殖生物学 生殖生物学
- 衰老的研究研究.
- 衰老的生物标志物
背景情况:
- 生殖增加了能源需求,可能加速细胞衰老.
- 端粒长度 (TL) 是生物衰老和健康的生物标志物.
- TL可以作为生殖努力的生物标志物.
研究的目的:
- 系统地审查怀孕期间的端粒动态.
- 为了评估平价和端粒长度之间的关联.
主要方法:
- 在七个数据库 (CINAHL,Cochrane,PsycINFO,Proquest,PubMed,Scopus,Web of Science) 进行系统搜索.
- 包括/排除标准适用于3431篇初始文章,导致14项研究进行最终审查.
- 使用纽卡斯尔-太华规模的质量评估和对4项关于平等和TL的研究 (2564名参与者) 的小型元分析.
主要成果:
- 在11项关于平价和TL的研究中,4项显示出负相关性 (更多的孩子,更短的TL),1项呈阳性,6项没有相关性.
- 四项纵向研究发现,从怀孕早期到产后,TL没有显著变化.
- 分析显示,平价对TL的负面影响并不显著 (ES = -0.009,p = 0.126).
结论:
- 怀孕,平价和TL的混合结果可能是由于不同的方法.
- 需要改进研究设计,包括精确的平价定义和对混因子的调整.
- 进一步的研究应该澄清短期怀孕影响和长期对TL的平价影响.
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