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早期青春期女孩的脂质概况:系统性审查和元分析
Mei Jiang1, Ying Gao2, Kai Wang3
1Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
BMC endocrine disorders
|October 17, 2023
概括
女孩早期的青春期与高甘油,总胆固醇和LDL胆固醇水平有关. 早期干预对于减轻这些儿童心血管疾病风险至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 早期青春期 (PP) 与潜在的长期健康风险有关,包括心血管疾病 (CVD).
- 关于女孩的脂质样本和PP之间的关系存在不一致的发现.
- 了解这些关联对于早期风险评估和管理至关重要.
研究的目的:
- 进行一项元分析,评估早期青春期女孩的脂质特征变化.
- 为了比较PP和健康对照的女孩之间的甘油三 (TG),总胆固醇 (TC),高密度脂蛋白 (HDL) 和低密度脂蛋白 (LDL) 的水平.
主要方法:
- 在2022年6月之前,在EMBASE,Cochrane图书馆,PubMed和Web of Science进行了系统的文献搜索.
- 用一个随机效应模型 (DerSimonian-Laird) 来计算整体标准平均差异 (SMD).
- 为了探索异质性,进行了子组和灵敏度分析;评估了出版偏差.
主要成果:
- 分析包括14项研究,包括1023名PP女孩和806名对照.
- 显著升高的TG (SMD:0.28),TC (SMD:0.30) 和LDL (SMD:0.45) 水平被观察到女孩与PP.
- 高密度胆固醇水平没有显著差异 (SMD: -0.06);异质因素包括疾病类型,区域和BMI.
结论:
- 早期青春期的女孩表现出改变的脂质样本,具有更高的TG,TC和LDL水平.
- 这些发现强调了早期干预的必要性,以预防肥胖和减少患有PP的儿童心血管疾病的风险.
- 进一步的研究可能会阐明这种人群中脂质谱变化的特定贡献因素.
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