全癌症分析确定RNF43作为预后,治疗和免疫生物标志物
Yingting Xu1, Zhengjun Lin1, Yuqiao Ji1
1Department of Orthopedics, The Second Xiangya Hospital, Central South University, 139# Middle Renmin Road, Changsha, 410013, Hunan, People's Republic of China.
European journal of medical research
|October 18, 2023
概括
戒指蛋白43 (RNF43) 是多种癌症的关键预后因素. 它的表达影响瘤的免疫微环境,并预测免疫疗法和药物敏感性的反应,为癌症治疗提供了一个有前途的生物标志物.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 环指蛋白43 (RNF43) 是一种E3泛素联酶,涉及各种癌症.
- RNF43在免疫表型和免疫治疗反应中的泛癌作用尚不清楚.
研究的目的:
- 为了研究RNF43的表达,突变模式和跨癌症的预后意义.
- 探索RNF43与瘤免疫微环境和免疫治疗疗效的关联.
主要方法:
- 对TCGARNA-seq,突变和临床数据的分析.
- 使用cBioPortal进行基因改变,GSEA进行途径分析,ESTIMATE/CIBERSORT/TISIDB用于免疫相关性.
- 免疫组织化学 (IHC) 在临床队列中验证了RNF43表达.
主要成果:
- RNF43表现异常表达,是多种癌症的显著预后因素.
- RNF43突变,主要是截断,发生在4%的癌症中.
- RNF43表达与免疫细胞透 (CD8+ T细胞,B细胞,巨细胞) 相相关,并预测抗PD-1/PD-L1治疗疗效和药物敏感性.
结论:
- 在胰腺癌中,RNF43是重要的预后生物标志物.
- RNF43调节瘤免疫微环境,并显示出作为预测免疫疗法反应和药物敏感性的生物标志物的潜力.
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