在SARS-CoV-2疫苗接种后的癌症患者中探索血性变异:一项实践研究
Liliana Montella1, Carmela Dell'Aversana2,3, Daniela Pacella4
1Oncology Operative Unit, "Santa Maria delle Grazie" Hospital, Pozzuoli, Napoli, ASL NA2 NORD 80078, Italy. liliana.montella@aslnapoli2nord.it.
Infectious agents and cancer
|October 18, 2023
概括
在接受化疗的癌症患者中,SARS-CoV-2 mRNA疫苗可能会导致暂时的白血病. 疫苗接种后的监测对于监测这些脆弱人群和确保治疗的连续性至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 建议在接受活跃瘤治疗的癌症患者接种SARS-CoV-2疫苗.
- 营销后监测对于评估这种脆弱群体的疫苗安全性至关重要.
研究的目的:
- 分析SARS-CoV-2 mRNA疫苗对接受抗癌治疗的患者血液样本的实际影响.
- 评估与疫苗相关的不良事件及其与患者特征和治疗方案的关联.
主要方法:
- 在瘤治疗期间接受mRNA疫苗 (Pfizer-BioNTech,Moderna) 的136名患者的回顾性分析.
- 血液样本分析全血细胞计和白细胞差异疫苗接种前后.
- 对SARS-CoV-2感染和随时间变化的血清学标位进行监测.
主要成果:
- 在接受化疗和化疗免疫治疗的患者中,在第一剂和第二剂mRNA疫苗接种后观察到显著的白血病.
- 白血病的发生是独立于人口因素 (性别,年龄,BMI).
- 在化学免疫疗法组中,同时出现的免疫介导疾病与第二剂后的白血病相关.
结论:
- 在接受化疗的癌症患者中,mRNA疫苗接种可能导致过渡性白血病,特别是在第二剂后.
- 虽然通常是安全的,但建议对这种人群进行白细胞计数的监测.
- 需要进一步的前性研究来了解疫苗和癌症治疗之间的复杂相互作用.
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