微生物种群的非马科夫模型中的进化动态
Farshid Jafarpour1, Ethan Levien2, Ariel Amir3,4
1Institute for Theoretical Physics, Utrecht University, 3584 CC Utrecht, The Netherlands.
Physical review. E
|October 18, 2023
概括
微生物进化不能简化为单个适应性参数,因为细胞分裂速率的波动. 单细胞动态显著影响进化结果,影响遗传漂移和突变固定.
科学领域:
- 微生物种群动态 微生物种群动态
- 进化生物学是进化的生物学.
- 理论生物学的理论生物学.
背景情况:
- 在微生物中量化单细胞生长和分裂动态已经取得了重大进展.
- 了解单细胞过程对于破译微生物进化史至关重要.
- 将单细胞动态与人口层面的进化过程联系起来至关重要.
研究的目的:
- 为了研究微生物进化动态是否可以使用单个适应性参数来简化.
- 在一个包含单细胞动态的模型中分析突变种群的行为.
- 为了确定长期的健康是否能够捕捉到自然选择和遗传漂移的力量.
主要方法:
- 在有限种群中开发微生物生长的数学模型.
- 将单细胞生长和分裂动态明确纳入模型.
- 在不同的环境条件下分析突变种群的行为.
主要成果:
- 由于人口平均分裂率的波动,无法定义一个统一的适应性参数来决定一个生物体的命运.
- 代代时间的变化增加了中性突变的遗传漂移率.
- 生成时间的变化降低了有益突变的固定概率.
结论:
- 微生物的进化动态不能完全粗地归结为一个单一的健康参数.
- 单细胞分裂速率的变化对突变物命运具有独立的影响,超出了长期生长速度.
- 分析解决方案的固定概率,概括欧勒-洛特卡方程,是导出的.
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