每日摄入Bifidobacterium和食纤维对血管内皮功能的影响:一个随机,双盲,安慰剂控制,并行组比较研究
Naoki Azuma1, Yasuo Saito1, Tomohiko Nishijima2
1R&D Laboratory, Ezaki Glico Co., Ltd., Osaka, Japan.
Bioscience, biotechnology, and biochemistry
|October 18, 2023
概括
每天饮用一个含有益生菌的饮料Bifidobacterium animalis subsp. 乳糖GCL2505和益生菌胰岛素在12周内显著改善了健康成年人的血管内皮功能.
科学领域:
- 微生物学 微生物学
- 人类营养人类营养
- 心血管健康 心血管健康
背景情况:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 众所周知,Lactis GCL2505可以调节肠道微生物群并减少内脏脂肪.
- 益生菌食纤维如胰岛素支持有益的肠道细菌生长.
- 血管内皮功能是心血管健康的关键指标.
研究的目的:
- 为了研究胰岛素和Bifidobacterium animalis亚种的联合作用. 乳糖GCL2505对健康个体的血管内皮功能.
- 评估流媒体扩张的变化,内皮功能的主要标志物.
- 探索对相关血液参数的影响,如胆固醇和PAI-1.
主要方法:
- 这是一项为期12周的随机,双盲,安慰剂控制,并行组研究.
- 参与者 (n=60) 每天饮用含有胰岛素和GCL2505的测试饮料或安慰剂.
- 流媒体扩张被测量为主要终点.
主要成果:
- 与安慰剂组相比,食用胰岛素和GCL2505组合的组显示流媒体扩张的显著增加.
- 在低密度脂蛋白胆固醇水平中观察到改善的趋势.
- 在等离子体激活剂抑制剂-1中也注意到了积极的趋势.
结论:
- 每天摄入含有胰岛素和Bifidobacterium animalis亚种的测试饮料. 乳糖GCL2505对血管内皮功能产生积极影响.
- 这种益生菌和益生菌组合可能对心血管健康标志物有好处.
- 进一步的研究可以探索长期影响和作用机制.
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