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Updated: Jul 13, 2025

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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[在子宫内膜癌的分子分类中对不匹配修复和微卫星不稳定状态的全面评估]

Y Liu1, Y X Wang1, X J Sun1

  • 1Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, Beijing 100191, China.

Zhonghua fu chan ke za zhi
|October 18, 2023
PubMed
概括

在不匹配修复 (MMR) 蛋白质免疫组织化学 (IHC) 和微卫星不稳定性 (MSI) 下一代测序 (NGS) 在子宫内膜癌 (EC) 中存在很高的一致性. 不一致的病例,通常是由于MLH1促进物甲基化,需要进行组合测试以准确的分子亚型.

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相关概念视频

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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