用抗药物治疗的儿童的眼部血液动力学
Pembe Gultutan1, Pinar Nalcacioglu2, Mehmet Icoz3
1Department of Pediatric Neurology, Ankara City Hospital, Children's Hospital, Ankara, Türkiye.
European journal of ophthalmology
|October 18, 2023
概括
接受酸或卡巴马西平治疗的患者表现出周周状视网膜神经纤维层 (p-RNFL) 厚度降低. 瓦尔酸还与这些患者的胆道血管性降低相关.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 是一种影响全球数百万人的神经系统疾病.
- 抗药物 (AED) 对于治疗至关重要,但可能会对眼部产生副作用.
- 光学连贯断层扫描血管学 (OCT-A) 允许对视网膜和胆道血管系统进行非侵入性评估.
研究的目的:
- 量化评估视网膜和胆道血管密度 (VD) 和视网膜厚度在患有的儿童在三个不同的AEDs.
- 将这些OCT-A和二元化成像测量与健康对照的测量进行比较.
- 研究与治疗相关的潜在药物特异性眼部微血管变化.
主要方法:
- 这是一项涉及124名参与者的观测性,横截面研究 (30名卡巴马泽,31名莱维他,32名瓦尔酸,31名对照).
- OCT-A用于对表面和深层毛细管,胸毛细管和半径周毛细管进行自动化微结构分析.
- 增强的深度成像 (EDI) -OCT和ImageJ软件用于斑点和胸腔血管结构二元化.
主要成果:
- 两组之间没有年龄,性别或持续时间的显著差异.
- 观察到周周状视网膜神经纤维层 (p-RNFL) 厚度和周周总视网膜厚度 (Trt) 的统计学上显著差异.
- 接受卡巴马西平和烯酸治疗的患者表现出降低p-RNFL厚度;使用烯酸的患者显示出最低的光面积和冠状血管指数 (CVI).
结论:
- 卡巴马泽平和酸与儿科患者的p-RNFL稀释有关.
- 斑点和辐射周血管密度没有受到这些AED的显著影响.
- 在患者中使用瓦尔酸与胆道血管血流的减少有关.
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