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布尼亚维拉莱斯:大型多样化的动物性病毒群的科学差距和原型病原体
Amy L Hartman1,2, Peter J Myler3,4
1Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
The Journal of infectious diseases
|October 18, 2023
概括
为了为未来的流行病做好准备,研究人员在Bunyavirales序列中确定了原型病毒. 这些被选中的病原体代表了不同的临床结果,适合开发针对新出现的病毒威胁的平台疫苗.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 流行病的准备 流行病的准备
背景情况:
- 国家过敏和传染病研究所 (NIAID) 正在为未来的流行病做好准备制定战略.
- 布尼亚维拉莱斯 (Bunyavirales) 序列包括四个家族 (Phenuiviridae,Peribunyaviridae,Nairoviridae和Hantaviridae),呈现出各种各样的新兴病毒威胁.
- 识别合适的原型病原体对于开发广泛的对策至关重要.
研究的目的:
- 确定四个Bunyavirales家族中的原型物种,这些物种代表了临床结果的范围.
- 选择适应疫苗开发和测试平台方法的病毒.
- 为未来研究和开发流行病对策提供基础.
主要方法:
- 对Bunyavirales家族 (Phenuiviridae,Peribunyaviridae,Nairoviridae,Hantaviridae) 的系统审查.
- 基于临床结果多样性的潜在原型物种的评估.
- 对每个家族的现有逆转基因工具和动物模型的评估.
- 考虑对基于平台的疫苗测试策略的适应性.
主要成果:
- 在四个Bunyavirales家族中划分潜在的原型物种.
- 用已有的研究工具和模型识别病毒.
- 选择适合用于疫苗开发平台方法的候选人.
- 建立进一步讨论和研究的起点.
结论:
- 拟议的原型病原体为NIAID的流行病准备工作提供了一个战略性的起点.
- 这些原型代表了Bunyavirales的多样性,并促进了基于平台的对策的开发.
- 对这些选定的原型进行进一步的研究和讨论对于推动针对新出现的病毒威胁的疫苗开发至关重要.
关键词:
一个Bunyavirus病毒汉塔病毒 汉塔病毒尼罗病毒病毒 (nairovirus) 是一种周边世界病毒 (peribunyavirus) 是一种病毒.弗莱博病毒 (Phlebovirus) 是一种病毒.更多相关视频
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