Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Bacteriophages of the Human Virome01:23

Bacteriophages of the Human Virome

Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Development and Qualification of a Nipah Virus Glycoprotein-Specific IgG ELISA for the Assessment of Human Antibody Responses.

Vaccines·2026
Same author

Potent in vitro antiviral activity of 4'-Fluorouridine against diverse orthohantaviruses including Andes virus.

Antiviral research·2026
Same author

Targeted cleavage site mutations in the Gn precursor enable efficient generation of replication-competent rVSV-based surrogates for emerging nairoviruses.

Emerging microbes & infections·2026
Same author

Distinct respiratory and neurological disease phenotypes in lethal Nipah virus Malaysia versus Bangladesh infection in IFNAR knockout mice.

Antiviral research·2026
Same author

Nucleoprotein and glycoprotein based serological assays for detection of Marburg virus infections.

EBioMedicine·2026
Same author

Confirming ERVEBO Vaccination to Support Ebola Virus Surveillance.

Emerging infectious diseases·2026

相关实验视频

Updated: Jun 20, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

36.3K

菲洛病毒:科学差距和原型病原体建议

Lesley C Dupuy1, Christina F Spiropoulou2, Jonathan S Towner2

  • 1Virology Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

The Journal of infectious diseases
|October 18, 2023
PubMed
概括

像埃博拉病毒和马尔堡病毒这样的filoviridae病毒会引起严重的出血性发烧. 本次审查确定了关键的知识差距和潜在的候选人,为抗击这些高优先病原体的流行病预备做好准备.

关键词:
埃博拉病毒埃博拉病毒.马尔堡病毒病毒苏丹病毒 苏丹病毒菲洛病毒是非病毒病毒.原型病原体的原型病原体科学的差距 科学的差距

更多相关视频

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
09:36

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

17.0K
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.1K

相关实验视频

Last Updated: Jun 20, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

36.3K
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
09:36

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

17.0K
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.1K

科学领域:

  • 病毒学 病毒学
  • 传染性疾病 传染性疾病
  • 公共卫生 公共卫生

背景情况:

  • 菲洛病毒,包括埃博拉病毒 (EBOV) 和马尔堡病毒 (MARV),是高毒的病原体,对人类和灵长类动物的严重出血发烧负责.
  • 撒哈拉以南非洲地区的疫情呈现出高病例死亡率 (25-90%),频率和地理分布不断增加,需要强有力的流行病准备.
  • 尽管被指定为高优先级的病原体,但仍然存在重大科学知识差距,涉及菲洛病毒生物学和病原性.

研究的目的:

  • 为了确定关键的科学知识关于filoviruses的空白.
  • 评估这种病毒家族的潜在原型病原体候选者.
  • 为传染病毒疾病的流行病准备策略提供信息.

主要方法:

  • 这项研究是对现有科学文献的综述.
  • 它合成了关于filovirus特征,疫情和研究局限性的信息.
  • 根据现有数据评估潜在的原型病原体.

主要成果:

  • 在了解菲洛病毒病原体,传播和对策方面,仍然存在重大科学差距.
  • 某些filovirus菌株被确定为潜在的原型病原体,需要进一步调查.
  • 该审查强调了研究极其需要的领域,以改善诊断,治疗和疫苗.

结论:

  • 解决filovirus研究中的科学差距对于有效的流行病准备至关重要.
  • 进一步研究原型菲洛病毒病原体对于疫苗和治疗开发至关重要.
  • 加强全球合作和研究资金对于减轻菲洛病毒疾病的威胁至关重要.