用激光二极管和全身化疗治疗早期双边视网膜母细胞瘤的保守治疗:一项为期14年的前性队列研究
Thi Anh Thu Phan1, Alexis Derumigny2, Minh Cuong Duong3
1Department of Ophthalmology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Cancer reports (Hoboken, N.J.)
|October 18, 2023
概括
使用热疗和化疗进行视网膜母细胞瘤 (RB) 的保守治疗是安全有效的,在资源不足的环境中保护眼睛和视力. 长期跟踪至关重要,痕回归模式表明治疗成功.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
背景情况:
- 关于保守性视网膜母细胞瘤 (RB) 治疗安全性和有效性的证据有限,特别是在资源有限的地区.
- 热疗与全身化疗相结合,为RB提供了一种潜在的眼睛保护方法.
研究的目的:
- 评估越南RB的保守治疗结果.
- 确定治疗成功的预测因子,以在低资源环境中保护眼睛和视力.
主要方法:
- 一项前性队列研究,涉及50名双边RB患者,在2005年至2019年期间接受治疗.
- 患者接受了热疗法和六次全身化疗.
- 通过标准化问卷收集的数据,平均随访时间为60个月.
主要成果:
- 总体而言,5年全球救援率达到了91.9%.
- 82%的眼睛实现了最终视力敏度≥0.1.1.
- 瘤回归到4型痕与更好的视力敏度和较低的核化率相关.
结论:
- 早期RB的保守治疗是安全有效的.
- 长期的患者随访对于监测治疗结果至关重要.
- 痕回归模式可以作为治疗有效性和潜在失败的指标.
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