SARS-CoV-2 感染与男性良性前列腺增生症恶化相关
Alex Qinyang Liu1, Peter Ka-Fung Chiu1, Samuel Chi-Hang Yee1
1S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, New Territories, Hong Kong SAR.
Journal of internal medicine
|October 18, 2023
概括
严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 感染显著增加男性尿路滞留,血和尿路感染的风险. 这些泌尿系统并发症无论COVID-19的严重程度如何都会发生,这突显了病毒的广泛影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 小规模研究表明,SARS-CoV-2可能会恶化男性下尿道症状 (LUTS).
- SARS-CoV-2 对良性前列腺激增症 (BPH) 并发症的影响需要进一步调查.
- 需要真实世界的数据来理解SARS-CoV-2和男性泌尿健康之间的关联.
研究的目的:
- 研究SARS-CoV-2感染与男性BPH并发症之间的相关性.
- 分析大规模的现实世界数据,以评估COVID-19的泌尿学影响.
- 为了确定SARS-CoV-2感染是否导致BPH相关不良事件的增加.
主要方法:
- 在香港 (2021-2022) 针对LUTS进行阿尔法阻断剂单疗的男性患者的回顾性队列研究.
- 患者被分为SARS-CoV-2阳性 (PCR确认) 和对照组.
- 倾向性得分匹配用于平衡共变量,然后对BPH并发症发生率进行比较.
主要成果:
- SARS-CoV-2 感染与尿 (4.55% vs 0.86%),血 (1.36% vs 0.41%),临床尿路感染 (4.31% vs 1.49%) 和培养证明的细菌性尿病 (9.02% vs 1.97%) 的发生率显著更高.
- 在SARS-CoV-2组中,添加5α减少酶抑制剂 (5ARI) 的比例也更高 (0.50%对0.02%).
- 这些差异在不同年龄组中持续存在,并且独立于COVID-19的严重程度.
结论:
- SARS-CoV-2 感染与短时间内尿,血和尿道感染的增加有关.
- COVID-19可能需要更频繁地添加组合疗法 (例如,5ARI).
- 这项研究提供了大量证据,证明SARS-CoV-2感染对男性的有害泌尿学影响.
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