更高的肥胖类与更严重的食道症状和反流负担有关,但没有改变运动功能或收缩储备
Brent Hiramoto1,2, Walker D Redd2,3, Mayssan Muftah1,2
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
肥胖会增加食道症状和反流负担,影响生活质量. 然而,它似乎不会对食道运动或功能产生负面影响.
科学领域:
- 胃肠病学和食道生理学
- 肥胖医学和患者结果
背景情况:
- 肥胖经常与食道症状有关,异常反流和运动障碍被怀疑是原因.
- 以前关于肥胖对食道功能和症状的影响的研究由于研究局限性而产生了不一致的结果.
研究的目的:
- 研究肥胖与客观食道功能之间的关系.
- 为了将客观的食道功能与患者报告的不同BMI个体的结果相关联.
主要方法:
- 针对接受高分辨率阻抗测量 (HRiM) 和多通道内阻抗pH监测 (MII-pH) 的成年人进行了前性研究.
- 经过验证的问卷评估了症状 (GERDQ,RSI,DSI,GSS) 和与健康有关的生活质量 (HR-QOL,SF-12).
- 消化管功能指标在BMI类别之间进行了比较,并与患者报告的数据相关联.
主要成果:
- 较高的肥胖类别显示增加了反流负担 (酸暴露,反流发作,玻尿酸暴露) 和缺口的患病率.
- 患有II/III类肥胖症的患者在HRiM上表现出更正常/超收缩的吞和更好的球体运输.
- 体重指数与症状严重程度得分 (GERDQ,RSI,DSI,GSS) 有正相关,与身体HR-QOL (SF-12) 有负相关.
结论:
- 肥胖与更大的食道症状负担和降低身体生活质量有关.
- 这些症状和生活质量损害与增加的酸性和玻尿酸反流负担相关.
- 肥胖似乎与食道运动,过渡或收缩储备的改变无关.
更多相关视频
11:19Robotic Myotomy and Partial Fundoplication for Achalasia
Published on: August 11, 2023
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
相关概念视频
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
