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D-二聚合物,C反应蛋白和矩阵金属蛋白酶9用于预测A型大动脉剖析患者的存活率

Minjie Huang¹, Yujie Lian¹, Zhongyan Zeng¹

¹Department of Vascular Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Fujian East Street, Quanzhou, 362000, Fujian, China.

ESC heart failure

|October 18, 2023

概括

生物标志物C-反应蛋白 (CRP),d-二分体和矩阵金属蛋白酶9 (MMP9) 可以预测急性A型大动脉剖析 (ATAAD) 患者的生存率. 综合测量为手术后1年生存期提供了最高的预测值.

科学领域:

心血管外科心血管外科
胸部外科手术胸部外科手术
大动脉疾病研究研究

背景情况:

急性A型大动脉解剖 (ATAAD) 是一种严重的外科紧急情况,具有显著的术后死亡率 (9-30%).
确定手术前的生物标志物对于评估ATAAD患者的术后生存至关重要.

研究的目的:

调查C-反应蛋白 (CRP),d-二次体和矩阵金属蛋白酶9 (MMP9) 的综合测量与ATAAD患者的1年生存率之间的关联.
评估这些生物标志物对ATAAD死亡率的预测价值.

主要方法:

对247名接受手术的ATAAD患者进行了回顾性分析.
对CRP,d-二次体和MMP9水平的相关性分析.
接收器操作特征 (ROC) 分析,以评估单个生物标志物的预测价值及其1年生存的组合模型.

主要成果:

与幸存者相比,已故的ATAAD患者的年龄更高,高血压的患病率更高,手术前CRP,d-二分体和MMP9的水平更高.
在CRP,d-二元和MMP9.9之间发现了显著的正相关性.
结合CRP,d-二次体和MMP9的检测模型显示出1年生存率的最高预测值 (AUC = 0.88).

结论:

结合测量CRP,d-二分体和MMP9显著与ATAAD患者的1年生存率相关.
这种生物标志物面板为在ATAAD中进行手术前风险分层和生存预测提供了有价值的工具.

关键词:

动脉剖析是一个大动脉剖析.在C-反应性蛋白 (CRP) 中.矩阵金属蛋白酶9 (MMP9) 的作用.d-Dimer 是一个模拟器.

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