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合成和优化1-替代的伊米达佐[4,5-c]林TLR7激动剂的合成和优化

Emma G DeYoung1, Justin M Howe1, Siteng Fang1

  • 1Binghamton University School of Pharmacy and Pharmaceutical Sciences, Johnson City, New York 13790, United States.

ACS medicinal chemistry letters
|October 18, 2023
PubMed
概括

研究人员开发了新型的托尔类受体7 (TLR7) 激动剂,用于抗体药物合物 (ADC) 疗法,其强度提高. 疏水性乙尾改善了TLR7激动剂的活性,从而产生了强大的抗癌剂.

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