超凝血状态与缺血性中风的严重程度与COVID-19感染之间的相关性
1Department of Neurology, Medical Faculty, Universitas Padjadjaran, Bandung, Indonesia.
Journal of blood medicine
|October 18, 2023
概括
患有急性缺血性中风的COVID-19患者通常会发展出高凝血状态,增加死亡风险. 虽然它与最初的中风严重程度无关,但它与出院时的更糟糕结果相关.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 在大多数急性缺血性中风患者中,COVID-19与高凝血状态有关.
- 这种高凝血状态可能会影响这些患者的严重程度和临床结果.
- 患有COVID-19感染的缺血性中风患者表现出较差的预后,特别是死亡率,当存在高凝血状态时.
研究的目的:
- 调查高凝血状态与COVID-19患者急性缺血性中风的严重程度之间的关系.
主要方法:
- 追溯性,横截面的分析研究.
- 包括急性缺血性中风患者,确诊的COVID-19,以及D-二聚合物/纤维素素水平.
- 分析数据使用奇平方测试进行关系分析.
主要成果:
- 87.5%的患者 (28/32) 呈现出高凝血状态 (D-二聚合物/纤维素因子升高).
- 在入院时,高凝血状态和中风严重程度之间没有发现显著的关系 (NIHSS入院).
- 在高凝血状态和中风严重程度之间观察到显著的关系 (NIHSS退出,p=0.02),并且在高凝血状态的患者中观察到高死亡率 (40.62%).
结论:
- 患有COVID-19的急性缺血性中风患者的高凝血状态与最初的中风严重程度没有显著的关系.
- 然而,它与出院时的神经状态密切相关,并与死亡率增加有关.
- 这些发现强调了监测COVID-19中风患者的高凝血能力的重要性,以改善临床管理和结果.
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