挥发性有机化合物分析对非传染性疾病的多功能性和诊断潜力
Micah Oxner1, Allyson Trang1, Jhalak Mehta1
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.
BME frontiers
|October 18, 2023
概括
身体中的挥发性有机化合物 (VOC) 提供了对代谢健康和疾病的见解. 本综述探讨了用于非侵入性诊断的VOC检测,重点关注癌症,并扩展到神经退行性疾病.
科学领域:
- 生物化学 生物化学
- 分析化学 分析化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 人体不断排放挥发性有机化合物 (VOC),反映了新陈代谢状态.
- 了解生物VOCs的起源和检测对于医疗应用至关重要.
- 目前关于VOC生产和来源的知识缺乏科学共识.
研究的目的:
- 审查最近生物挥发性有机化合物的来源和检测方面的进展.
- 探索VOC资料在非侵入性疾病歧视方面的潜力.
- 总结VOC癌症研究及其扩展到神经退行性和非传染性疾病.
主要方法:
- 对呼吸,尿液,血液,便和皮肤中的VOC最新文献的分析.
- 基于传感器的诊断技术与传统方法 (如气色谱-质谱法 (GC-MS)) 的比较.
主要成果:
- 挥发性有机化合物 (VOC) 概况可以表明代谢条件和疾病状态.
- 分析技术的进步使得在各种生物样本中能够进行敏感的VOC检测.
- 基于传感器的方法为GC-MS用于VOC分析提供了有希望的,具有成本效益的替代方案.
结论:
- 挥发性有机化合物分析对个性化查和诊断具有重大潜力.
- 需要进一步的研究来确定VOC作为可靠的临床诊断工具.
- 未来的优先事项包括完善检测方法和了解特定疾病的VOC生物标志物.
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