相关实验视频

Updated: Jul 13, 2025

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

人类癌症功能性药物检测器官类型模型

Yu Ling Huang¹, Lindsay K Dickerson², Heidi Kenerson²

¹Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, USA.

|October 18, 2023

概括

开发针对个性化瘤学的临床相关平台至关重要. 有希望的器官类型培养方法正在出现,以测试个体的癌症药物敏感性,旨在改善患者的治疗结果.

科学领域:

在瘤学瘤学.
翻译医学是一种翻译医学.
癌症研究癌症研究

背景情况:

个性化瘤学需要对个别癌症进行准确的药物敏感性测试.
目前的诊断工具缺乏全面的平台来指导治疗决策.
尽量减少治疗毒性和成本,需要可靠的预测测定.

研究的目的:

审查使用完整的人类癌症组织进行药物敏感性测试的当前策略.
突出器官类型培养作为临床相关平台的潜力.
讨论人类癌症建模和反应评估方面的进展.

主要方法:

总结了利用完整的人类瘤组织的器官类型培养的各种方法.
审查用于在体外评估和分析瘤反应的技术.
专注于保存瘤微环境的方法.

主要成果:

人类癌症组织的器官类型培养显示出对药物敏感性测试的前景.
癌症建模和反应评估技术的进步正在使新的方法成为可能.
目前还没有一个单一的平台可用于广泛的临床应用.

结论:

有机型培养物代表了个性化癌症治疗的前沿前沿.
需要进一步开发,以便将这些模型转化为常规的临床实践.
这些模型有可能指导瘤学家选择有效的治疗方法.

更多相关视频

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Published on: December 23, 2022

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

Published on: July 5, 2019

相关概念视频

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...