对三剂CoronaVac疫苗天生的免疫反应的长度评估
Cheng Cao1,2, Junfeng Jiang1,3, Min Liu4
1Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, Jiangsu, China.
Frontiers in immunology
|October 18, 2023
概括
用CoronaVac接种COVID-19疫苗改变了先天性免疫细胞的分布,特别是单细胞和NK细胞. 辅助剂量显著增强了产生干扰素的NK细胞反应.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 对非活化COVID-19疫苗的自适应性免疫反应得到了充分证实.
- 接种COVID-19疫苗对先天性免疫细胞的影响仍未得到充分研究.
- 了解天生的免疫力对于疫苗开发至关重要.
研究的目的:
- 为了研究三剂 CoronaVac 疫苗接种对外围单细胞和 NK 细胞的纵向影响.
- 为了分析COVID-19疫苗接种后天生的免疫细胞子集的变化.
- 评估NK细胞的反应,特别是IFN-γ的产生,在同源的CoronaVac剂量后.
主要方法:
- 招募了62名接受了三剂CoronaVac疫苗的医疗保健工作者.
- 纵向配置的外围单细胞和自然杀手 (NK) 细胞.
- 在免疫细胞中分析了子集分布和细胞因子生产 (IFN-γ).
主要成果:
- 接种疫苗后观察到单细胞和NK细胞亚群分布的显著变化.
- 在整个疫苗接种过程中,单细胞和NK细胞的总频率保持稳定.
- 第二剂和第三剂的CoronaVac都诱导了强烈的IFN-γ产生NK细胞反应.
结论:
- 三个同源的CoronaVac剂量诱导了先天免疫细胞群的显著变化.
- 强大的NK细胞反应,以IFN-γ的产生为特征,是由强剂引起的.
- 这些发现为未来针对SARS-CoV-2和其他病毒的非活化疫苗设计提供了免疫学见解.
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