移植后早期的系统性炎症与长期的移植损失有关:一项队列研究
Torbjørn F Heldal1,2,3, Anders Åsberg3,4,5, Thor Ueland2,6,7
1Department of Internal Medicine, Telemark Hospital Trust, Skien, Norway.
Frontiers in immunology
|October 18, 2023
概括
移植后早期的系统性炎症预示着长期的移植损失. 这种炎症也与活检结果相关,突出了它在移植病理和生存中的作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
背景情况:
- 长期代移植损失是复杂的,不同于由于拒绝或手术问题导致的早期移植损失.
- 系统性炎症对长期移植结果的作用需要进一步调查.
研究的目的:
- 为了检查早期系统性炎症和长期移植损失之间的关联.
- 为了将全身炎症得分与移植后6周和1年的活检结果相关联.
主要方法:
- 21个炎症生物标志物在移植后10周测量了699名脏移植接受者.
- 使用整体和途径特定得分评估的低级炎症.
- 考克斯回归模型用于分析与移植损失和活检数据的关联.
主要成果:
- 整体炎症评分与长期,死亡审查的移植损失显著相关 (HR1.03,P=0.005).
- 较高的炎症评分 (第四季度) 增加了移植损失的风险 (HR 3.19,P=0.005).
- 血管炎症得分与6周和1年的活检炎症相关;纤维生成得分与间歇性纤维化和管管缩有关.
结论:
- 移植后早期的全身炎症与活检确认的病理有关.
- 早期的全身炎症预示着长期的移植损失.
- 血管炎症得分显示,随着时间的推移,脏活检中的炎症变化与血管炎症得分有显著的相关性.
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