职业暴露对类风湿性关节炎和结性脊柱炎的因果关系:一项两样本的门德尔随机化研究
Kai Du1, Chen-Yu Zhang1, Ao Li1
1Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in immunology
|October 18, 2023
概括
这项研究调查了职业暴露及其与类风湿性关节炎 (RA) 和结性脊柱炎 (AS) 的因果关系. 门德尔随机化分析发现,涉及行走/站立,重型手工工作或轮班工作的工作与这些条件之间没有直接的因果关系.
科学领域:
- 流行病学 流行病学
- 遗传学 是一个遗传学.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 和性脊柱炎 (AS) 是具有复杂病因的慢性炎症性疾病.
- 职业暴露被怀疑是环境风险因素,但因果关系尚不清楚.
研究的目的:
- 调查三种特定的职业暴露与发展RA和AS的风险之间的潜在因果关系.
- 要区分主要涉及行走或站立 (JWS) 的工作,涉及重型手工或体力劳动 (JMP) 的工作,以及涉及轮班工作 (JSW) 的工作.
主要方法:
- 采用双样本门德尔随机化 (TSMR) 分析,使用单变量MR (UVMR) 和多变量MR (MVMR).
- 职业暴露和AS的全基因组关联研究 (GWAS) 数据来自英国生物银行,RA的数据来自芬兰Gen生物银行.
- 用了多种统计方法,包括反变量加权 (IVW) 和MR-Egger,以进行可靠的分析.
主要成果:
- 统变MR分析表明,研究的职业暴露与RA或AS之间没有显著的因果关系.
- 双向MR分析也未能确定因果关系.
- 虽然未调整的多变量MR表明重型手工劳动和AS之间存在潜在联系,但调整后的分析以及所有其他分析都没有发现因果关系的证据.
结论:
- 门德尔的随机化分析没有支持涉及行走/站立,重型手工工作或轮班工作的工作与RA或AS的发展之间的直接因果关系.
- 可能需要进一步的研究来探索其他潜在的职业风险因素或潜在的机制.
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