环二的最新进展:用于药物研究的生物活性化合物
Si-Xuan Liu1, Si-Yi Ou-Yang1, Yong-Fu Lu1
1Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.
Frontiers in microbiology
|October 18, 2023
概括
本综述详细介绍了真菌和细菌循环的最新进展,突出了它们的多样性结构和重要的生物活动,如抗瘤和抗真菌特性.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 药用化学 医学化学
背景情况:
- 环二是从氧和氨基酸中形成的天然产品.
- 这些化合物是由真菌和细菌产生的.
- 许多环节表现出强烈的生物活性,包括抗瘤,抗真菌,抗病毒,抗疟疾和抗松体效应.
研究的目的:
- 审查最近 (2010-2022) 关于来自真菌和细菌来源的环二的文献.
- 巩固关于这些化合物的结构多样性的知识.
- 为了记录非海洋环二的生物活动和来源.
主要方法:
- 在科学数据库中进行文献搜索,寻找2010年至2022年的相关出版物.
- 对已识别的结构信息和生物活动的物品进行分析.
- 不包括从海洋生物中提取的环氧化.
主要成果:
- 从真菌和细菌中分离出来的众多环二的汇编.
- 详细描述它们的结构特征,包括胺和 ester 连接.
- 报告的广泛生物活动的总结.
结论:
- 菌和细菌的环二是一种丰富的生物活性分子来源.
- 对这些化合物的持续研究可能会产生新的治疗剂.
- 本综述提供了对该领域近期进展的全面概述.
相关概念视频
Drug Discovery: Overview
8.0K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.0K
Structure-Activity Relationships and Drug Design
735
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
735
Positive Regulator Molecules
5.5K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.5K
Prodrugs
2.6K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Prodrugs help overcome...
2.6K
Transducer Mechanism: Enzyme-Linked Receptors
2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.5K


