基于MTHFR rs1801133单核酸多态性和MTHFR促进子甲基化对高血压的敏感性
Ming-Huang Chiu1, Chia-Hsiu Chang2, Disline Manli Tantoh3,4
1Department of Pulmonology and Respiratory Care, Cathay General Hospital, Taipei City, Taiwan.
Frontiers in cardiovascular medicine
|October 18, 2023
概括
MTHFR rs1801133 TT基因型增加了高血压的风险. 较低的MTHFR促进子甲基化,特别是CC基因型,也会增加高血压风险,这表明对高血压易感性的遗传和表观遗传影响.
科学领域:
- 遗传学和表观遗传学
- 心血管疾病研究研究
- 人类人口研究 人类人口研究
背景情况:
- 高血压的发病是多因素的,涉及遗传,表观遗传和环境因素.
- 遗传和表观遗传改变对高血压风险的综合影响仍然不完全理解.
- 本研究研究了台湾成年人中MTHFRrs1801133多态和MTHFR促进物甲基化之间的相互作用.
研究的目的:
- 评估MTHFR rs1801133单核酸多态化 (SNP) 和MTHFR促进物甲基化与高血压的独立和相互作用关联.
- 确定MTHFR基因中的遗传变异和表观遗传修饰如何导致高血压风险.
- 探索MTHFR在高血压发展中的遗传和表观遗传因素之间的潜在协同作用.
主要方法:
- 利用来自台湾生物银行 (TWB) 的1238个人的数据.
- 收集了关于MTHFR促进物甲基化,MTHFR rs1801133基因型 (CC,CT,TT),人口统计,生活方式和病史的信息.
- 采用统计分析来评估MTHFR标志物和高血压之间的关联和相互作用.
主要成果:
- MTHFR rs1801133 TT基因型独立地与显著更高的高血压风险相关 (OR = 2.718,95% CI = 1.503-4.914).
- 单独的MTHFR促进剂甲基化与高血压没有显著相关.
- 观察到一个显著的相互作用:较低的MTHFR促进剂甲基化增加了高血压的风险,在CC基因型的个体中依赖于剂量 (例如,OR
结论:
- MTHFR rs1801133多态,特别是TT基因型,是高血压的独立风险因素.
- 促进MTHFR甲基化对高血压风险产生显著影响,特别是在与特定基因型 (CC) 结合时.
- 这些发现强调了MTHFR遗传和表观遗传因素在调节高血压易感性方面的共同作用.
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