对Chromolaena odorata的水性和甲醇提取物的植物化学,生物学和毒性研究
Akash Budha Magar1, Deepa Shrestha1, Sangita Pakka1
1Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
TheScientificWorldJournal
|October 18, 2023
概括
药用植物Chromolaena odorata由于其丰富的和黄含量,对抗细菌感染和糖尿病具有显著的潜力. 这项研究验证了其传统用途,突出了其药理价值.
科学领域:
- 民族植物学和植物化学.
- 药理学和毒理学 药理学和毒理学
背景情况:
- 在全球范围内,Chromolaena odorata的传统用途用于各种疾病.
- 需要对其药理性质进行科学验证.
研究的目的:
- 进行C. odorata提取物的植物化学分析.
- 评估抗氧化剂,抗糖尿病,抗菌和毒性概况.
- 为了评估植物的药理潜力.
主要方法:
- 使用甲醇和蒸水进行提取.
- 总 (TPC) 和黄 (TFC) 含量的量测量.
- 对抗氧化活性进行DPPH测定,对抗糖尿病活性进行α-葡萄糖酶抑制.
- 对抗细菌活性和盐水毒性测试的阿加尔井扩散.
主要成果:
- 叶子和花的甲醇提取物显示TPC和TFC最高.
- 观察到显著的DPPH自由基清除活动.
- 具有有效的抗菌活性,可以对抗K. pneumoniae,B. subtilis和E. coli.
- 花的甲醇提取物显示出显著的α-葡萄糖酶抑制.
- 水性鲜花提取物表现出有毒性 (LC50 = 107.31 ± 49.04 μg/mL).
结论:
- 香味是一种富含和黄的丰富来源,具有潜在的药用应用.
- 这项研究科学验证了传染病和糖尿病的传统用途.
- 提取物显示有前途的药理学活动,支持进一步的研究.
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