甲状腺参数与临床下动脉样硬化在2型糖尿病患者住院治疗的甲状腺腺患者中的关联
Jing Du1, Xin Zhao1, Xiumei Xu1
1Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|October 18, 2023
概括
在2型糖尿病患者中,低水平的自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 与亚临床动脉样硬化相关. 这种情况的FT3/FT4比率显示出强大的预测值.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 亚临床动脉样硬化 (AS) 是2型糖尿病 (T2DM) 患者的重大并发症.
- 甲状腺激素在新陈代谢调节和心血管健康方面发挥着至关重要的作用.
- 在正常甲状腺功能的T2DM患者中,甲状腺功能和AS之间的关系需要进一步阐明.
研究的目的:
- 调查甲状腺参数与亚临床动脉样硬化 (AS) 之间的关联.
- 在被诊断患有2型糖尿病 (T2DM) 的住院euthyroid患者中探索这种关联.
主要方法:
- 对1245名住院的T2DM患者,甲状腺功能正常的回顾性分析.
- 测量自由三甲状腺素 (FT3),自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH) 的水平.
- 动脉超声扫描用于AS评估和评估甲状腺激素敏感度,使用FT3/FT4比率等指数.
主要成果:
- 在T2DM患者中,亚临床AS发病率随着FT3,FT4和FT3/FT4水平的提高而下降.
- FT4,FT3和FT3/FT4比率独立地与亚临床AS风险降低有关.
- 与单独使用FT3或FT4相比,FT3/FT4比率显示出亚临床AS的更高的预测准确性.
结论:
- 在无甲状腺T2DM患者中,亚临床AS与FT3,FT4和FT3/FT4水平负相关.
- 这些甲状腺激素水平与亚临床AS有关,而不依赖于其他危险因素.
- FT3/FT4比率是该患者群体中亚临床AS的有价值预测指标.
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