量化内部椎间盘菌株以评估核置换器件设计:数字体积相关性和超高分辨率MRI研究
Tamanna Rahman1,2, Saman Tavana1,2, Nicoleta Baxan3,4
1Department of Bioengineering, Imperial College London, London, United Kingdom.
Frontiers in bioengineering and biotechnology
|October 18, 2023
概括
核置换器械 (NRD) 在去除核后恢复椎间盘 (IVD) 高度和生物机械应变. 这项研究表明,NRD可以使菌株正常化,支持其作为退化的IVD可行的治疗潜力.
科学领域:
- 生物医学工程 生物医学工程
- 整形外科手术 整形外科手术
- 放射学 放射学是一门学科.
背景情况:
- 退行性椎间盘 (IVD) 疾病导致疼痛和生物机械功能障碍.
- 核置换装置 (NRD) 旨在恢复IVD功能,但临床成功是有限的.
- 了解NRD与组织的相互作用对于改善植入物设计和患者的治疗结果至关重要.
研究的目的:
- 在核置换手术期间,在人体尸体IVD中进行3D菌株的非侵入性量化.
- 评估核切除和随后的NRD植入的生物力学影响.
- 评估NRDs恢复本地IVD生物力学的潜力.
主要方法:
- 使用数字体积相关性 (DVC) 与高场9.4TMRI相结合.
- 七个人体尸体IVD标本被轴向压缩到1kN.
- 在完整状态,核切除术后状态和NRD后状态下测量了菌株.
主要成果:
- 核去除显著降低了圆盘高度,这被NRD恢复.
- 核切除术增加了annulus fibrosus中的环形和剪切菌株.
- 该NRD成功地将这些改变的菌株值恢复到与完整状态相比的水平.
结论:
- 核置换手术可以恢复IVD高度,并使生物力学菌株正常化.
- DVC-MRI技术是评估NRD性能的一个有价值的工具.
- 这些发现支持核替代作为退化的IVD可行的治疗方法,并指导未来的NRD设计.
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