在ADPKD中心血管表现和管理
Priyanka S Sagar1,2,3, Gopala K Rangan1,2
1Michael Stern Laboratory for Polycystic Kidney Disease, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Kidney international reports
|October 18, 2023
概括
自体主导多囊性病 (ADPKD) 中的心血管疾病 (CVD) 是由高血压和多囊素功能障碍驱动的. 对高血压,左心室缩和内动脉瘤的管理指南对于ADPKD患者至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
背景情况:
- 心血管疾病 (CVD) 是自体主导多囊性病 (ADPKD) 死亡的主要原因.
- 关键的表现包括高血压,左心室缩 (LVH),内动脉瘤 (ICAs),膜心脏病和心肌病.
- 高血压是最常见的表现形式,也是ADPKD的一个显著可修改的风险因素.
研究的目的:
- 审查ADPKD中高血压和外心血管和血管疾病的复杂病原性.
- 综合关于ADPKD相关心血管并发症的临床前,临床和流行病学证据.
- 描述现有的ADPKD特定的查和管理指南.
主要方法:
- 临床前,临床和流行病学研究的文献综述.
- 分析了氨酸- ангиотензин- алдостерон系统 (RAAS),内皮细胞功能障碍,交感神经系统 (SNS),氧化 (NO),内皮素-1 (ET-1) 和不对称二甲基氨基 (ADMA) 的作用.
- 检查心血管表现的流行趋势.
主要成果:
- 氨酸- ангиотензин- алдостерон系统 (RAAS) 和与多囊素相关的内皮细胞功能障碍是ADPKD心血管疾病的主要驱动因素.
- 交感神经系统 (SNS),氧化 (NO),内甲素-1 (ET-1) 和不对称的二甲基氨基 (ADMA) 起着重要的作用.
- 降低的LVH率可能与抗高血压疗法有关,而增加的缺血性心肌病患病率与更长的存活率有关.
结论:
- 高血压和心血管并发症是ADPKD病变的组成部分.
- 了解多因素驱动因素是管理ADPKD心血管风险的关键.
- 遵守ADPKD特定的高血压,LVH和ICAs查和管理指南至关重要.
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