在SARS-CoV-2感染后肝功能障碍患者的结果:我们应该测量什么?
Nimy John1, Brittney Ibrahim2, Mark Ebaid2
1Department of Medicine, University of California, Los Angeles, CA, USA.
Hepatic medicine : evidence and research
|October 18, 2023
概括
COVID-19 感染可能会导致肝功能障碍,通常由肝酶升高表明. 患有慢性肝病的患者面临更高的COVID-19严重疾病和死亡风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 自2019年以来,COVID-19流行病给全球健康带来了许多挑战.
- 在流行病的早期观察到肝脏表现.
- 了解COVID-19中的肝功能障碍对于患者管理至关重要.
研究的目的:
- 为了分类与COVID-19相关的肝功能障碍.
- 分析COVID-19患者肝功能障碍的结果.
- 审查有关COVID-19相关肝损伤的文献.
主要方法:
- 对PubMed和Medline数据库的文献评论.
- 包括详细介绍短期和长期结果的文章.
- 专注于COVID-19相关的肝功能障碍.
主要成果:
- 升高的阿斯巴酸氨基转移酶 (AST) 是最常见的肝脏发现.
- 肝酶的升高通常会随着COVID-19的恢复而消失.
- 其他表现包括COVID-19胆血管病变,自身免疫性肝炎和状静脉血栓症.
- 以前存在的肝病,特别是肝硬化,与较差的COVID-19预后有关.
- 升高的肝检测与COVID-19的严重程度相关.
- 患有慢性肝病的患者患病率和死亡率增加.
- 特定的慢性肝病,如脱补偿性肝硬化,肝细胞癌和与酒精有关的肝病增加了COVID-19的风险.
- 需要考虑COVID-19抗病毒药物和肝炎药物之间的潜在药物相互作用.
- 已经报告了COVID-19疫苗接种相关的肝功能障碍.
结论:
- 在COVID-19中,肝功能障碍是严重感染的标志物.
- 患有慢性肝病的人患COVID-19的死亡率较高.
- 从大流行中吸取的教训对于当前和未来的患者护理至关重要.
- 需要进一步研究COVID-19肝功能障碍患者的长期结果.
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