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甲状腺刺激激素与甲状腺结节,和甲状腺抗体阳性之间的关联
Shaohan Li1, Wenxing Guo1, Qi Meng1
1Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.
Frontiers in endocrinology
|October 18, 2023
概括
正常的甲状腺刺激激素 (TSH) 水平仍然可以表明甲状腺疾病的风险. 低TSH与甲状腺结节和有关,而高TSH与成人甲状腺抗体有关.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 在成年人中,正常的甲状腺刺激激素 (TSH) 水平与甲状腺疾病之间的关联是有争议的.
- 甲状腺疾病,包括甲状腺结节 (TN),喉 (GR) 和甲状腺抗体阳性,是常见的健康问题.
研究的目的:
- 研究血清TSH水平在正常范围内与中国成年人甲状腺疾病患病率之间的相关性.
- 为了确定与TN,GR和甲状腺抗体阳性的风险增加相关的特定TSH范围.
主要方法:
- 一项涉及中国天津2460名成年受试者的横截面研究.
- 甲状腺超声波用于评估甲状腺体积 (Tvol) 和TN.
- 分析了血清TSH,甲状腺功能和尿液中水平.
主要成果:
- 在2220名正常TSH的受试者中,较低的TSH水平 (0.27-1.41 IU/mL) 是TN (OR 1.46) 和GR (OR 5.90) 的风险因素.
- 较高的TSH水平 (2.55-4.2 IU/mL) 与甲状腺抗体阳性 (OR 1.53) 有关.
- 特定的人口群体 (如女性,老年人,男性,年轻人) 根据TSH水平显示出不同疾病的不同风险.
结论:
- 在正常的TSH范围内,低水平与TN和GR的风险增加有关.
- 高的正常TSH水平与较高的甲状腺抗体阳性风险有关.
- 建议对TSH水平处于正常范围的上限或下限的成年人进行定期监测.
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