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硬件,软件和湿件编码设计环境用于合成生物学

Samuel M D Oliveira^1,2, Douglas Densmore^1,2

¹Department of Electrical and Computer Engineering, Boston University, MA 02215, USA.

Biodesign research

|October 18, 2023

概括

合成生物学通过生物设计自动化,集成软件,机器人学和微流体学来取得进展. 这种"硬件,软件,湿器"的方法使得基因电路的自动设计能够用于各种应用.

科学领域:

合成生物学和生物工程.
计算生物学和生物信息学.
在生命科学领域的自动化和机器人.

背景情况:

合成生物学使生物系统的工程能够用于材料,农业,医学和能源领域的应用.
传统的生物设计往往是缓慢和代的.
从嵌入式电子设计中借鉴原则可以加速生物工程.

研究的目的:

为合成生物学提供"硬件,软件,湿器"代码设计框架.
通过整合软件,机器人和微流体技术来引入"生物设计自动化".
从单一规范中实现硬件,软件和湿器的并行生成.

主要方法:

开发"遗传编译器"以将高级规范转化为遗传电路 (wetware).
设计自动化设备,工作流程和微流体设备 (硬件) 用于电路执行和测试.
实施调度和控制算法 (软件) 用于系统管理和数据分析.

主要成果:

一个统一的"硬件,软件,湿器"编码设计方法,从单一规范中衍生出来.
允许平行生成适合特定成本,性能和结构需求的生物系统.
大规模并行实验平台或分布式生物传感/生物修复设备的潜力.

结论:

生物设计自动化为加速生物系统工程提供了一个强大的范式.
综合代码设计方法简化了复杂合成生物学应用程序的创建.
这一框架有助于开发具有可预测和可定制功能的未来生物系统.

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