内镜同注册超声波成像和精确基因组:初步的体内评估
Thomas G Landry1,2, Jessica Gannon3, Eli Vlaisavljevich3
1School of Biomedical Engineering, Dalhousie University, Canada.
BME frontiers
|October 18, 2023
概括
这项研究引入了一种内镜系统,将超声波成像和基因组结合起来,用于精确的非热性脑组织切除. 这种新型设备能够准确地定位和执行最少入侵的神经外科手术程序.
科学领域:
- 神经外科 神经外科
- 医疗成像医学成像
- 生物医学工程 生物医学工程
背景情况:
- 基因组术提供安全的,非热的组织切除.
- 神经外科的应用受到头骨透和装置尺寸的限制.
- 最少侵入性手术需要先进的准工具.
研究的目的:
- 评估一种新型内镜系统,用于同时进行高分辨率超声波成像和组织缩切除.
- 在临床前的老鼠大脑模型中评估系统的性能.
- 确定神经外科手术中精确,非热性废除的可行性.
主要方法:
- 开发了一种直径为10毫米的6.3MHz组状垂体内镜,配备一个中央的30MHz超声波成像阵列.
- 在麻醉的老鼠大脑上进行了切除,并通过超声波监测进展.
- 分析了组织学断面,以检测切除特征和附带损伤.
主要成果:
- 在几秒钟内实现了完整的亚毫米除,即使有设备移动.
- 通过使用功率多普勒和B模式成像,可以实时监测切除和出血.
- 观察到最小的附带损伤,细胞损伤延伸至100微米.
结论:
- 开发的系统对精确的内镜切除有很大的前景.
- 这项技术支持组织缩,神经科学和瘤学的临床前研究.
- 该硬件能够准确地针对最少侵入性的神经外科干预进行准确的准.
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