使用可解释的人工智能识别人类支气管的年龄相关特征
Hiroaki Ikushima1,2, Kazuhiro Usui1
1Department of Respiratory Medicine, NTT Medical Center Tokyo, Tokyo, Japan.
ERJ open research
|October 18, 2023
概括
研究人员开发了一种人工智能模型,从支气管镜像中评估支气管年龄,确定支气管分支部位作为关键的年龄依赖特征. 这为量化与年龄相关的肺部变化提供了一种新的方法.
科学领域:
- 肺部医学 肺部医学
- 人工智能的人工智能
- 医疗成像医学成像
背景情况:
- 衰老会导致器官变化,但对支气管衰老缺乏定量测试.
- 支气管镜像为评估与年龄相关的支气管变化提供了潜在的数据来源.
研究的目的:
- 在支气管图像上使用可解释的AI识别支气管中依赖年龄的特征.
- 开发一种定量方法来评估与年龄相关的支气管变化.
主要方法:
- 利用 11,374 个支气管镜像用于训练和测试深度学习模型 (CNNs).
- 从图像中计算出"支气管年龄",并将其与时间年龄相关联.
- 使用Grad-CAM可视化AI模型识别的年龄依赖特征.
主要成果:
- 深度学习模型,特别是EfficientNetB3,显示了支气管和时间年龄之间的高相关性 (0.9617).
- 可解释的人工智能 (Grad-CAM) 突出显示了支气管分支部位作为关键的年龄相关特征.
- 在不同呼吸道疾病或吸烟史中,没有发现年龄预测差异的显著差异.
结论:
- 支气管分支部位是支气管中普遍存在的年龄依赖的特征.
- 这种人工智能驱动的方法为评估支气管衰老提供了一种新的定量方法.
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