在HARP队列中,基于LMS的酸盐恒温参数的儿科参考值
Veronika Pott1, Helene Tietze1, Nele Kanzelmeyer1
1Department of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, 30625 Hannover, Germany.
The Journal of clinical endocrinology and metabolism
|October 18, 2023
概括
这项研究为酸盐稳态建立了新的儿科参考百分位数,有助于对儿童实验室结果的准确解释. 这些连续值有助于评估整个开发过程中的酸盐含量和相关参数.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 临床化学 临床化学
- 生物统计学 生物统计学
背景情况:
- 由于发育变化和缺乏参考值,评估儿童的酸盐稳态是复杂的.
- 对实验室参数的准确解释对于儿科健康管理至关重要.
研究的目的:
- 开发基于Lambda-Mu-Sigma (LMS) 的连续儿科参考百分位数,用于七个关键的酸盐平衡实验室参数.
- 为改善儿童和青少年的测试结果解释提供标准化的z分数.
主要方法:
- 一项横截面研究 (汉诺威儿科参考值 - HARP) 包括455名年龄在0.1-18岁的儿童.
- 基于LMS的连续参考百分位被计算为血清酸盐,iFGF23,sKlotho,TmP/GFR,TRP,Ca/Crea和Pi/Crea.
- 数据分析的重点是这些参数的年龄和性别依赖.
主要成果:
- 基于LMS的百分位数和z-score被确定为所有七个参数,证明年龄依赖.
- 血清酸盐,TmP/GFR和sKlotho显示与性别有关.
- 血清酸盐,TmP/GFR和尿液Ca/Crea/Pi/Crea的水平在婴儿期是最高的,在18岁时下降,在一些参数方面,女孩更早达到成人水平.
结论:
- 本研究提出了首个基于LMS的连续儿科参考百分位,用于关键的酸盐稳态参数.
- 这些百分位使得标准化z-score计算成为可能,使儿科实验室结果的准确解释更加容易.
- 这些发现支持改善儿童酸盐相关疾病的临床评估和管理.
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