上一篇 缺血性中风显著改变新诊断的癌症患者中风风险
Ronda Lun1,2,3, Joshua O Cerasuolo4,5, Marc Carrier6,7
1Division of Neurology, Department of Medicine, The Ottawa Hospital Research Institute, ON, Canada (R.L., M.S., D.D.).
Stroke
|October 18, 2023
概括
患有缺血性中风 (IS) 史的个人在接受新癌症诊断后面临再次中风的风险几乎增加了三倍. 当前中风发生在癌症诊断前一年内时,这种风险最高.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 心血管医学 心血管医学
背景情况:
- 以前的缺血性中风 (IS) 是一般人群中随后的IS的已知风险因素.
- 癌症患者以前的IS和未来的IS风险之间的关系仍然不清楚.
研究的目的:
- 为了检查史前缺血性中风 (IS) 与癌症新诊断的个体后续IS风险之间的关联.
主要方法:
- 在加拿大安大略省 (2010-2020年) 进行了回顾性,基于人口的匹配队列研究.
- 将13070名癌症患者与52455名癌症患者进行匹配.
- 使用累积发病率函数和细分调整的危险比率 (aHRs),将死亡视为竞争事件.
主要成果:
- 在癌症诊断后,先前有IS的个体有显著增加IS的风险 (aHR,2.68).
- 在妇科 (aHR, 3.84) 和肺癌 (aHR, 3.18) 小组中观察到最高的中风风险.
- 脑卒中风险与滞后时间相反相关;在癌症诊断前1年内发生的IS显示出最高风险 (aHR,3.68).
结论:
- 患有缺血性中风 (IS) 的病史将在新的癌症诊断后经历随后中风的风险几乎增加三倍.
- 风险特别高,如果预诊断中风发生在癌症诊断前一年内.
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