根据血糖状况,身体活动与关节骨折风险之间的关联:全国性队列研究
Kyoung Min Kim1, Kyoung Jin Kim2, Kyungdo Han3
1Division of Endocrinology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi-do 16995, Republic of Korea.
The Journal of clinical endocrinology and metabolism
|October 18, 2023
概括
定期体力活动 (PA) 显著降低关节骨折 (HF) 风险,特别是在5年或更长时间患有2型糖尿病 (DM) 的人群中. 这种保护作用在这种糖尿病人群中最为明显.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
背景情况:
- 众所周知,身体活动 (PA) 可以降低骨折风险.
- 基于血糖状况的PA对骨折风险的差异影响尚不清楚.
研究的目的:
- 为了研究身体活动 (PA) 如何影响不同的血糖状况中发生骨折 (HF) 的风险.
- 为了确定PA在预防关节骨折方面的益处是否在正常葡萄糖耐受性,禁食葡萄糖受损以及2型糖尿病 (DM) 不同持续时间的个体之间有所不同.
主要方法:
- 一项大规模的队列研究,包括3723097名50岁以上的患者,没有1型糖尿病或先前骨折.
- 参与者被分为五个血糖状况分层,包括正常的葡萄糖耐受性和2型糖尿病的不同阶段.
- 使用国际体育活动问卷 (IPAQ-SF) 评估体育活动水平,并使用Cox比例危险回归分析部骨折风险.
主要成果:
- 最低的体力活动水平 (<500 MET-min/wk) 与最高的关节骨折风险有关.
- 虽然PA的益处在糖分组之间显示出一些变化,但在5年或更长的2型DM患者中观察到PA和HF风险之间的一致反向关系.
- 在5年或更长的2型DM患者中,PA对关节骨折的保护作用最为显著,男性和女性的调整后危险比率为0.74,与最不活跃组相比.
结论:
- 较高的体力活动水平与部骨折风险降低有关.
- 身体活动的骨折保护益处在糖尿病患者中最为显著,特别是那些患有长期2型糖尿病 (≥5年) 的患者.
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