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嗅觉歧视和识别作为长期残疾的生物标志物,在多发性硬化症中恶化
Klaus Berek1, Harald Hegen1, Michael Auer1
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Multiple sclerosis (Houndmills, Basingstoke, England)
|October 18, 2023
概括
多发性硬化症 (MS) 患者的嗅觉识别能力下降预示着长期残疾恶化,包括不依赖复发活动和认知衰退的进展. 这种嗅觉标记标志着随着时间的推移而发生的神经轴损伤.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 嗅觉研究 嗅觉研究
背景情况:
- 嗅觉功能障碍,特别是嗅觉区分和识别 (DI),被认为是多发性硬化症 (MS) 中残疾和神经轴损伤恶化的标志物.
- 了解MS进展中的嗅觉变化的预测价值对于患者管理和治疗策略至关重要.
研究的目的:
- 调查嗅觉区分和识别 (DI) 的纵向变化是否可以预测多发性硬化症 (MS) 患者的长期疾病过程.
主要方法:
- 在因斯布鲁克多发性硬化诊所对多发性硬化患者进行了为期6年的前性纵向研究.
- 临床数据,包括扩展残疾状态量表 (EDSS) 评分,每两年评估一次.
- 气味DI和认知功能在基线,1年,2年和6年使用"嗅探棒"测试和符号数字模式测试进行了评估.
主要成果:
- 在6年的研究期间,平均气味DI得分显著下降 (p < 0.001),并且与患者的年龄和疾病持续时间负相关.
- 较低的绝对DI分数和随着时间的推移更大的DI分数损失与更高的EDSS恶化概率,不依赖复发活动的进展 (PIRA) 和6年认知恶化有关.
- 气味DI变化与第一次复发的时间之间没有发现显著的关联.
结论:
- 嗅觉区分和识别 (DI) 作为MS中神经轴损伤的不可逆转标记.
- 嗅觉功能障碍与MS患者的复发活动 (PIRA) 独立的进展,认知恶化和扩大残疾状态量表 (EDSS) 评分的恶化有显著的关联.
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