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Updated: Jul 13, 2025

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缺氧使SETDB1稳定,以保持基因组的稳定性.

Sungryul Park1, Jin Hwa Cho1, Jong-Hwan Kim2

  • 1Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

Nucleic acids research
|October 18, 2023
PubMed
概括

希佩尔-林道 (VHL) 瘤抑制剂针对SETDB1进行降解,这是维持基因组稳定性至关重要的过程. 缺氧导致VHL功能丧失导致SETDB1积累,引发免疫反应和DNA损伤.

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