相关实验视频

Updated: Jul 13, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

TheMarker:一个治疗生物标记物的全面数据库

Yintao Zhang^1,2, Ying Zhou^1,3, Yuan Zhou¹

¹College of Pharmaceutical Sciences, The First Affiliated Hospital, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China.

Nucleic acids research

|October 18, 2023

概括

一个新的数据库,TheMarker,系统地分类五种类型的治疗生物标志物 (ThMARs),对于药物发现和临床实践至关重要. 该资源提供了各种疾病类别的综合数据,有助于治疗开发.

科学领域:

生物标志物发现和开发
药理学和治疗学药理学和治疗学
药物开发和临床试验

背景情况:

治疗生物标志物 (ThMARs) 对于药物开发和临床实践至关重要,与传统的诊断/预后生物标志物不同.
存在五种关键类型的ThMAR:药理学,安全性,监测性,预测性和替代性终点,每个都在药物发现中发挥着至关重要的作用.
现有的数据库缺乏对不同药物开发阶段和疾病类别的ThMARs的全面描述.

研究的目的:

构建和介绍"TheMarker",一个专门用于治疗生物标志物 (ThMARs) 的新型数据库.
在药物开发过程中使用的所有五种类型的ThMAR系统地编目.
为大量药物提供全面的ThMAR信息,涵盖广泛的疾病类别.

主要方法:

开发一个名为"TheMarker"的集中数据库.
系统地收集和组织五种不同类型的治疗生物标志物的数据.
包括ThMAR信息用于广泛的药物和疾病类别.

主要成果:

TheMarker数据库提供了对所有五种ThMAR类型的系统覆盖.
它为大量药物提供了全面的ThMAR信息,超过了现有的数据库.
该数据库广泛涵盖了各种疾病类别,不仅仅是抗癌疗法.

结论:

TheMarker数据库为治疗生物标记信息提供了一个有价值的,全面的资源.
预计其广泛的数据和广泛的疾病覆盖范围将对药物发现和临床实践产生重大影响.
该数据库是免费访问的,促进在研发中的更广泛使用.

更多相关视频

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

相关概念视频

Therapeutic Index

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...