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Updated: Jul 13, 2025

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MethMotif.Org 2024:一个数据库,将特定的转录因子结合动机与DNA甲基化模式集成在一起

Matthew Dyer1, Quy Xiao Xuan Lin2, Sofiia Shapoval1

  • 1Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada.

Nucleic acids research
|October 18, 2023
PubMed
概括

现在MethMotif提供了700多个转录因子 (TF) 结合配置文件和DNA甲基化数据. 该数据库通过整合人类,小鼠和Arabidopsis.mouse的表观遗传信息和辅因子状态来增强对TF功能的理解.

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Epigenetic Regulation

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X-chromosome...
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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