优化在广泛的成年人体型范围内的anidulafungin暴露
Ronald G Hall1, Shuhan Liu2, William C Putnam1
1Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center , Dallas, Texas, USA.
在肥胖患者中,安尼杜拉金的剂量可能低于最佳. 对于较高瘦身或调整体重的成年人,建议使用更高的剂量 (150-200毫克),以确保对侵入性真菌感染的有效治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 安尼杜拉金是一种关键的 Echinocandin 抗真菌药物,用于候选性血病.
- 目前的剂量可能不适合不同体型的个体,特别是肥胖者.
研究的目的:
- 评估Anidulafungin药理动力学 (PK) 在广泛的成年人体型.
- 为了确定体型对anidulafungin暴露的影响,并优化剂量策略.
主要方法:
- 一组20名成年人接受了一次100毫克的anidulafungin剂量,并在72小时内进行密集的PK采样.
- 人口PK分析确定了体型指标 (LBW,AdjBW) 作为关键共变量.
- 蒙特卡洛模拟评估了各种剂量方案实现目标 (PTA) 的概率.
主要成果:
- 随着身体大小的增加,无黄素的暴露 (AUC0-∞) 减少.
- 瘦身体重 (LBW) 和调整体重 (AdjBW) 是对anidulafungin PK的显著预测因素.
- 标准100毫克剂量在LBW>55公斤或AdjBW>75公斤的成年人中产生<90%的PTA.
结论:
- 安尼杜拉金的药理动力学受到人体大小的影响,需要调整剂量.
- 建议更重的成年人服用更高的维持剂量 (150-200毫克),以达到目标PTA.
- 优化剂量可以提高各种患者群体的侵入性角膜炎的治疗疗效.
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