在年轻成年人中量化骨强度缺陷 极度早产或极低出生体重
Thang Dao1, Dale Lee Robinson2, Lex W Doyle3,4,5,6
1Melbourne Medical School, The University of Melbourne, Melbourne, Australia.
概括
极度早产 (EP) 或极低出生体重 (ELBW) 的年轻人显示骨强度降低,增加长期骨折风险,特别是在男性中. 对EP/ELBW幸存者的骨健康评估对于早期干预至关重要.
科学领域:
- 骨健康研究 骨健康研究
- 过早分娩的结果
- 成人的骨发育成长
背景情况:
- 自20世纪90年代以来,极其早产 (EP;<28周怀孕) 或极低出生体重 (ELBW;<1000g) 的成年人的长期骨健康状况尚不清楚.
- 基于外围定量计算断层扫描 (pQCT) 的有限元素建模 (pQCT-FEM) 是评估骨脆弱性的验证技术.
研究的目的:
- 为了研究骨结构和估计出生于EP/ELBW的年轻成年人的骨强度.
- 为了比较EP/ELBW幸存者和25岁末期出生对照者之间的骨参数.
主要方法:
- 一项队列研究涉及161名EP/ELBW幸存者和122名出生后的对照者 (出生于1991-1992).
- 在长度的4%和66%的骨和半径的pQCT分析,使用pQCT-FEM进行刚度计算 (压缩,扭曲,曲).
- 对身高和体重进行调整的线性回归,以性别作为交互术语来评估群体差异.
主要成果:
- 与对照组相比,EP/ELBW幸存者较矮,但体重相似.
- 在EP/ELBW幸存者中,高度和重量调整后的扭曲刚度在骨的66%显著较低 (-180Nm/deg).
- 骨扭曲和曲刚性的群体差异在男性中比女性更明显,在辐射骨参数上没有显著差异.
结论:
- 在EP/ELBW幸存者中,更低的调整骨强度指标表明预测的长期骨折风险的临床相关增加,特别是在男性中.
- 推在未来的pQCT-FEM研究中采用部pQCT图像,因为在辐射测量中观察到的变异性更大.
- 研究结果强调需要在成年后继续监测EP/ELBW人群的骨健康状况.
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