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表观遗传学和形式的进化:对染色质修饰的实验性操纵导致面骨的物种特异性变化

Leah DeLorenzo¹, Kara E Powder¹

¹Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.

Evolution & development

|October 18, 2023

概括

表观基因组素乙化会影响鱼的头骨面部发育,在某些物种中会引起形变化,但在其他物种中却不会. 这突显了物种对形态进化的表观遗传调节的特定敏感性.

科学领域:

进化生物学是进化的生物学.
发育生物学是发展生物学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

表型多样性源于遗传和表观遗传因素.
一种表观遗传机制 - - 基因组乙化 (histone acetylation) 正在研究其在脊椎动物分歧中的作用.
类动物表现出多样化的面结构,使他们成为适应性辐射研究的模型.

研究的目的:

为了研究素乙化对面形态变异对类动物的影响.
评估抑制组织基因脱乙烯化对两种甲虫物种发育的面部结构的影响.
确定表观遗传对发育影响的物种和时间依赖性.

主要方法:

发育中的甲状腺体暴露于基酸A (TSA),一种基因素脱乙烯化抑制剂.
在三个关键的发育窗口期间进行治疗:神经细胞迁移,迁移后的NCC增殖和早期的冠状元形成.
在两个物种,Maylandia和Tropheops的面结构的形态分析.

主要成果:

在NCC迁移和扩散期间的TSA暴露诱导了Maylandia中的小形形形面部变化 (较短的头部,更宽的下巴,更的形状),但不是Tropheops.
当TSA在早期体发生过程中被应用时,没有观察到任何显著的形态变化.
影响似乎通过对NCC发展的间接影响来调解,可能包括发育迟缓.

结论:

素乙化对早期的面发育至关重要.
鱼的面发育表现出对表观遗传变化的特定物种敏感性.
表观遗传调节在适应性辐射期间产生和缓冲形态变异方面发挥着作用.

关键词:

这就是Evo-devo.适应适应适应适应这种类型的化物.基因素乙化基因素乙化基因素乙化形态学形态学形态学神经细胞是神经顶细胞.

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