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药物诱导睡眠内镜期间的气道缩与阻塞性睡眠呼吸暂停的临床特征有关

Manan Parekh¹, Vasiliki Triantafillou¹, Brendan T Keenan²

¹Department of Otorhinolaryngology - Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

The Laryngoscope

|October 18, 2023

概括

在睡眠内镜检查期间的气道压力正定位客观地测量了阻塞性睡眠呼吸暂停 (OSA) 中的气道缩性. 这些指标与OSA严重程度和患者风险因素相关,改善了诊断.

科学领域:

睡眠医学睡眠医学
耳鼻喉科耳鼻喉科耳鼻喉科
呼吸系统生理学呼吸系统生理学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与喉缩性增加有关.
药物诱导的睡眠内镜带有正气道压力 (DISE-PAP) 提供了气道缩性的客观指标.
关键指标包括喉开口压力 (PhOP) 和活性喉临界压力 (Pcrit_A).

研究的目的:

调查OSA风险因素,客观气道缩性测量和临床表现之间的关系.
确定患者人口统计和人体测量与可折叠度指标的相关性.
评估可折叠性和多睡眠学发现与患者报告的症状之间的关联.

主要方法:

对164名接受DISE-PAP治疗的OSA患者进行横截面分析.
用逐步的鼻腔PAP定位来确定PhOP.
Pcrit_A是从压力-流量关系中计算的;临床数据是从电子医疗记录中收集的.
使用多变量回归分析来检查变量之间的关系.

主要成果:

年龄较小和BMI较高与PhOP增加有关,但不是Pcrit_A.
PhOP和Pcrit_A都与呼吸暂停-呼吸暂停指数 (AHI),仰卧式呼吸暂停指数 (AHI) 和氧和极点 (SpO₂极点) 相相关.
较高的PhOP与增加的打严重程度有关.

结论:

在DISE-PAP期间对气道机械的客观评估实际上与OSA的临床风险因素有关.
定量可折叠性测量提高了接受睡眠手术的患者的评估.
这些发现支持DISE-PAP在为OSA评估提供有意义,客观数据方面的实用性.

关键词:

气道的可折叠性气道的可折叠性阻塞性睡眠呼吸暂停症是什么聚类人体图像 (polysomnography) 是一种多人体图像.睡眠内镜检查睡眠内镜检查

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