在尼克洛萨米德道溶酸盐中的溶解过程
Jen E Mann1, Renee Gao1, Shae S London1
1Department of Chemistry, Georgetown University, 37th and O Streets NW, Washington, District of Columbia 20057-1227, United States.
Molecular pharmaceutics
|October 18, 2023
概括
研究尼克洛萨米德 (NCL) 溶酸盐显示,与水合物形式不同的是,溶解是核化限制的. 不同的晶体结构影响固态溶解途径.
科学领域:
- 固态化学 固态化学
- 晶体学 晶体学是指结晶学.
- 材料科学 是一种材料科学.
背景情况:
- 尼克洛萨米德 (NCL) 呈现出多种道溶酸盐形式,没有一种是异构的.
- 了解溶解机制对于控制固态转换至关重要.
研究的目的:
- 为了阐明尼克洛萨米德甲醇和乙酸盐溶解物的脱溶机制.
- 为了将溶解途径与之前研究的NCL水合物进行比较.
主要方法:
- 时间分辨率的同步粉X射线衍射射线.
- 热重力测量是一种热重力测量.
- 在同热加热下进行动力数据分析.
主要成果:
- 溶解涉及复杂的分子轨迹与突然的格子参数转移.
- 溶解的主要速度受限于无溶剂产品的核化.
- NCL溶剂溶解与水合物溶解形成鲜明对比,水合物溶解涉及扩散和随后的相转换.
结论:
- 每个溶酸盐都起到独特的前体作用,影响溶解途径.
- 溶剂结合强度和密度会影响固态溶解过程.
- 这项研究提供了对控制制药化合物的固态转换的见解.
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