血管化:从交叉通道的角度来看
Shiqi Yang1,2, Zhaolin Zeng1, Qing Yuan1,2
1Department of Metabolism and Endocrinology, Hengyang Medical School, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China.
Molecular biomedicine
|October 18, 2023
概括
血管化涉及复杂的细胞通信,而不仅仅是单个细胞. 细胞外囊泡 (EVs) 调解这种交叉,为心血管疾病提供新的治疗和诊断潜力.
科学领域:
- 心血管生物学 心血管生物学
- 蜂通信 蜂通信
- 生物医学工程 生物医学工程
背景情况:
- 血管化 (VC) 显著增加了心血管疾病 (CVD) 的风险,但有效的治疗方法受到了解不足的分子机制的限制.
- 血管细胞的发育涉及血管微环境中的复杂的多细胞和多器官相互作用,超出了对血管光滑肌细胞 (VSMC) 的直接影响.
研究的目的:
- 通过细胞间通信 (交叉通话) 的透视来探索VC分子机制的新见解.
- 总结一下多种细胞类型和器官之间的相互作用如何通过细胞外囊泡 (EVs) 调节VC.
- 审查EV作为VC治疗策略的新兴潜力.
主要方法:
- 文献综述侧重于VC中的细胞交叉通话.
- 对细胞外囊泡 (EVs) 在VC中细胞间通信中介作用的分析.
- 关于VC相关措施和基于EV的治疗方法的临床前和临床研究的摘要.
主要成果:
- VC是一个复杂的过程,由多细胞通信网络驱动,而不仅仅是VSMC病理.
- 细胞外囊泡 (EVs) 在调解这种交叉声中发挥着至关重要的作用,在细胞之间传递信号和分子载荷.
- 电动汽车显示出作为治疗剂,药物输送系统和VC生物标志物的巨大潜力.
结论:
- 通过细胞交叉声和EV的角度了解VC,为治疗和诊断开辟了新的途径.
- 基于EV的疗法和诊断是管理VC和减少心血管疾病发病率和死亡率的有希望的前沿.
- 为了制定有效的反VC策略,对电动汽车中介通信的进一步研究至关重要.
相关概念视频
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
19
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
19
Overview of Cell-Matrix Interactions
7.3K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.3K
The Bone Matrix
3.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
3.2K
Atherosclerosis I: Introduction
9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9
Skeleton and Calcium Homeostasis
4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12


