血中水平与手握强度之间的关联在接受维护血液透析的患者中
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A Murine Model of Hemodialysis Access-Related Hand Dysfunction
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Ruiying Tang1, Jiexin Chen1, Huijuan Ma1
1Department of Nephrology, Jiangmen Central Hospital, Jiangmen, China.
International urology and nephrology
|October 18, 2023
概括
较高的血中含量与接受维护血液透析 (MHD) 的患者手握强度降低有关. 这一发现表明,可能会影响MHD患者的肌肉功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
- 肌肉骨健康 肌肉骨健康
背景情况:
- 维护血液透析 (MHD) 患者经常经历渐进的肌肉衰弱.
- 在MHD中肌肉损失背后的机制是多因素的.
- 以前的研究表明,在非透析人群中,血和肌肉力量之间存在联系.
研究的目的:
- 为了研究血液中含量与手握强度之间的联系,在接受MHD的患者中.
- 为了确定血中的升高是否是这个人群肌肉力量降低的危险因素.
主要方法:
- 一项对236名MHD患者的横截面研究.
- 血中含量通过感应合血质谱法测量.
- 根据血液中的度,患者被分为三层.
- 评估手握强度以评估肌肉状态.
- 包括斯皮尔曼和多变量线性回归在内的统计分析.
主要成果:
- 血中含量较高的患者 (三位数1) 更有可能是女性,有较长的透析年龄,Kt/V.较高.
- 较高的血三位数与较低的BMI,血清肌素,血红蛋白和手握强度有关.
- 观察到一个显著的反向关系:血液的每1ug/L增加与手握强度下降2.81公斤相关 (p=0.014).
结论:
- 血液中的含量与接受维护血液透析的患者手握强度降低有显著的关联.
- 这一发现表明毒性在MHD患者肌肉功能障碍中的潜在作用.
- 需要进一步的前性研究,使用更大的队列来证实这些结果并探索临床影响.
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