相关实验视频
Updated: Jul 13, 2025

09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
2.7K
肠-大脑轴是控制神经疾病中的肠道失调症的关键因素
Ieshita Pan1, Praveen Kumar Issac2, Md Mostafizur Rahman3
1Institute of Biotechnology, Department of Medical Biotechnology and Integrative Physiology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, India. ieshitapan.sse@saveetha.com.
Molecular neurobiology
|October 18, 2023
概括
帕金森病 (PD) 涉及肠道失调,影响大脑-肠轴. 微生物代谢物和饮食为这种神经退行性疾病提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,与多巴胺基神经元中的α-synuclein聚合有关.
- 肠道微生物群失生症越来越多地通过免疫,神经内分泌和神经通路与PD病原发生有关.
- 这种失生症可以导致肠道透性增加,全身炎症和多巴胺能神经元损失.
研究的目的:
- 在帕金森病中审查肠-大脑轴的双向通信通道.
- 突出肠道微生物代谢物的作用,作为PD的潜在治疗点.
- 为了强调饮食和迷走神经在调节这个轴上的影响.
主要方法:
- 在帕金森病中研究肠-大脑轴的研究文献综述.
- 对将肠道失调与神经炎症和α-synucleinopathy联系起来的机制的分析.
- 检查微生物代谢物,饮食和迷走神经的作用.
主要成果:
- 肠道功能障碍通过触发线粒体功能障碍和全身炎症,有助于PD.
- 阿尔法-同核素聚合受肠道微生物活动影响,影响肠道神经元和质细胞.
- 食纤维发酵产生短链脂肪酸 (SCFA),对肠道平衡和潜在的大脑功能至关重要.
结论:
- 由饮食和微生物代谢物如SCFA调节的肠-大脑轴,为帕金森病提供了一个有前途的治疗途径.
- 通过饮食干预和益生菌维持肠道平衡可能有助于控制PD症状和进展.
- 需要利用先进技术进行进一步的研究,以充分阐明肠道微生物组在神经退行性疾病中的作用.
相关概念视频
Physiology of Enteric Nervous System and Gut Health
279
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
279
Irritable Bowel Syndrome I: Introduction
284
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
284
Enteric Nervous System: Regulation of GI Motor Activity
406
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
406
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Nerve Supply of the GI Tract
1.4K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
1.4K
The Blood-brain Barrier
47.5K
Overview
47.5K

