症状性神经瘤的生物学和病理生理学
Charles D Hwang1, Yannick Albert J Hoftiezer2,3, Floris V Raasveld2,4
1Division of Plastic and Reconstructive Surgery, Department of General Surgery, Massachusetts General Hospital, Harvard University, Boston, MA, United States.
Pain
|October 18, 2023
概括
神经瘤导致严重的疼痛和残疾,目前的治疗方法提供有限的缓解. 对分子机制的进一步研究对于开发治疗神经瘤疼痛的有效疗法至关重要.
科学领域:
- 神经损伤和神经再生
- 治疗疼痛的药物 疼痛的药物
- 分子生物学分子生物学
背景情况:
- 神经瘤由于神经损伤和神经病痛而显著影响生活质量.
- 现有的神经瘤疼痛的手术和治疗选择是不够的,突出显示了对新型治疗的需求.
- 驱动神经瘤形成和相关疼痛的精确分子机制尚不清楚.
结论:
- 对于症状性神经瘤来说,急需改进治疗策略.
- 进一步调查神经瘤形成和疼痛的分子和遗传基础是必不可少的.
- 识别新的治疗点可能涉及调节神经营养因子,炎症通路和离子通道.
相关概念视频
The Neuromuscular Junction
9.8K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
9.8K
Neurogenesis and Regeneration of Nervous Tissue
836
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
836
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Neuromuscular Junction And Blockade
3.1K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
3.1K
Nervous Tissue: Myelin
2.7K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
2.7K


