在自闭症谱系障碍中大规模白质功能网络的改变
Kai Chen1, Wenwen Zhuang1, Yanfang Zhang2
1Mental Health Education Center and School of Big Health Management, Xihua University, Jinniu District, Chengdu, Sichuan, China.
Cerebral cortex (New York, N.Y. : 1991)
|October 18, 2023
概括
自闭症谱系障碍 (ASD) 与改变的白质网络有关. 这项研究发现,ASD患者在特定大脑网络中的连接性和自发活动下降,与社会缺陷相关.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育障碍,其特点是社会功能障碍.
- 以前的研究表明,自闭症的结构性白质变化.
- 在ASD中大规模白质功能网络的变化仍未得到充分研究.
研究的目的:
- 调查白质功能网络连接和自发活动在患有自闭症的个体.
- 确定受ASD影响的特定网络.
- 为了将网络变化与社会行为缺陷相关联.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据使用K-means集群分析,以确定十个白质功能网络.
- 白质,白质-灰质功能网络连接,以及ASD个体与健康对照之间的自发活动的比较.
- 网络措施与社会响应度表 (SRS) 分数之间的相关性分析.
主要成果:
- 与对照人群相比,在ASD患者的头,中前和深度网络中观察到白质和白质功能网络连接的显著下降.
- 在头和深层网络中发现白质-灰质功能网络连接性下降.
- 在患有自闭症的个体中,中前和深层网络的自发活动减少.
- 中等temporo-frontal网络中的连接性和深度网络中的自发活动与SRS分数相关.
结论:
- 白质功能网络的改变与自闭症谱系障碍有关.
- 特定的网络功能障碍,包括连接性和自发活动减少,可能是ASD社会缺陷的基础.
- 这些发现强调了研究ASD中大规模白质网络的重要性.
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